Major pain
The crossword clue "Major pain" is answered by AGONY, a 5-letter entry. Used 7 times across 7 distinct years; most recently in 2020; first recorded in 1998. It appears in 4 publications in the xd corpus. Every figure on this page comes from the collection data itself, never from a guess.
The answer
AGONY
5 letters. See every clue for this answer on the AGONY answer page.
Used 7 times across 7 distinct years; most recently in 2020; first recorded in 1998. It appears in 4 publications in the xd corpus. Frequency and last-seen figures come from the xd crossword corpus only.
Other answers for this clue
The same clue has also been answered these ways in the xd corpus. Answers inside this collection link to their own answer page.
Other clues for AGONY
Every other clue in this collection answered by AGONY, most used first.
- Torment - used 41 times, most recently in 2026
- Extreme pain - used 31 times, most recently in 2025
- Ecstasy's opposite - used 30 times, most recently in 2026
- Anguish - used 19 times, most recently in 2026
- Great pain - used 18 times, most recently in 2026
- Opposite of ecstasy - used 16 times, most recently in 2026
- Deep distress - used 14 times, most recently in 2026
- Intense pain - used 14 times, most recently in 2026
- Intense suffering - used 13 times, most recently in 2025
- Suffering - used 13 times, most recently in 2026
- "The __ and the Ecstasy" - used 13 times, most recently in 2024
- Great distress - used 11 times, most recently in 2025
- Extreme suffering - used 10 times, most recently in 2026
- Serious suffering - used 10 times, most recently in 2024
- ". . . the ___ of defeat" - used 10 times, most recently in 2024
- Excruciating pain - used 9 times, most recently in 2024
- Ecstasy's antithesis - used 8 times, most recently in 2025
- Ecstasy's counterpart - used 8 times, most recently in 2026
- Terrible pain - used 7 times, most recently in 2023
- Intense distress - used 6 times, most recently in 2006
- Pain - used 6 times, most recently in 2024
- Torture - used 6 times, most recently in 2013
Related clues
Clues in this collection of the same answer length that share a word with this clue, or match its answer pattern when no word is shared. Most used first.
- Major artery - AORTA, used 132 times
- Major blood vessel - AORTA, used 92 times
- Major happening - EVENT, used 42 times
- Pain relief brand - ALEVE, used 35 times
- Major mix-up - SNAFU, used 33 times
- Major mess - SNAFU, used 27 times
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