Operating room substance, once

The answer

ETHER

5 letters. See every clue for this answer on the ETHER answer page.

Used 7 times across 5 distinct years; most recently in 2014; first recorded in 1999. It appears in 2 publications in the xd corpus. Frequency and last-seen figures come from the xd crossword corpus only.

Other clues for ETHER

Every other clue in this collection answered by ETHER, most used first.

• Old anesthetic - used 156 times, most recently in 2026
• Clear sky - used 90 times, most recently in 2026
• Old-time anesthetic - used 76 times, most recently in 2025
• Early anesthetic - used 57 times, most recently in 2026
• Bygone anesthetic - used 48 times, most recently in 2026
• Former anesthetic - used 38 times, most recently in 2026
• Heavens - used 33 times, most recently in 2026
• Upper regions of space - used 31 times, most recently in 2026
• Anesthetic of old - used 30 times, most recently in 2026
• Anesthetic - used 23 times, most recently in 2006
• Erstwhile anesthetic - used 21 times, most recently in 2024
• Old number? - used 20 times, most recently in 2019
• Upper regions - used 18 times, most recently in 2025
• It'll knock you out - used 15 times, most recently in 2021
• Obsolete anesthetic - used 13 times, most recently in 2024
• The clear sky - used 13 times, most recently in 2000
• Wild blue yonder - used 13 times, most recently in 2020
• The heavens - used 12 times, most recently in 2016
• Anesthetic of yore - used 11 times, most recently in 2019
• Cyberspace - used 11 times, most recently in 2025
• Disappear into the ___ - used 11 times, most recently in 2026
• Once-popular anesthetic - used 9 times, most recently in 2024
• Upper space - used 9 times, most recently in 1990
• Anesthesia of old - used 8 times, most recently in 2015
• Common solvent - used 8 times, most recently in 2026
• Flammable solvent - used 8 times, most recently in 2025
• It's a gas - used 8 times, most recently in 2016
• It's a knockout - used 7 times, most recently in 2020
• Old-time anaesthetic - used 7 times, most recently in 2018
• Upper atmosphere - used 7 times, most recently in 2024
• Chloroform kin - used 6 times, most recently in 2014
• Clear blue sky - used 6 times, most recently in 2018
• Knockout gas - used 6 times, most recently in 2011
• Old-fashioned anesthetic - used 6 times, most recently in 2026
• Old-style anesthetic - used 6 times, most recently in 2005
• Upper region of space - used 6 times, most recently in 2017
• Upper sky - used 6 times, most recently in 2025

Related clues

Clues in this collection of the same answer length that share a word with this clue, or match its answer pattern when no word is shared. Most used first.

• Once more - AGAIN, used 336 times
• Room at the top - ATTIC, used 75 times
• Drawing room - SALON, used 58 times
• "Once upon --" - ATIME, used 45 times
• "Once ___ time . . . " - UPONA, used 39 times
• Not even once - NEVER, used 31 times

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